Endocrine Abstracts

Background: Adrenocortical carcinoma (ACC) is a rare malignant tumour of the adrenal cortex with an incidence of 0.7-2.0 per million per year. The majority are steroid-producing with non-ACTH dependent hypercortisolism the most frequent biochemical abnormality. Around 10-15% of cases are picked up incidentally on abdominal imaging. Management of ACC during the covid-19 pandemic poses specific challenges. We present the case of a 69-year-old man who was found to have a massive ...

Introduction: We describe the case of a patient referred to Cardiology with an abnormal ECG & hypertension. Investigation led to the diagnosis of catecholamine induced cardiomyopathy caused by a pheochromocytoma. The case is unique as the cardiomyopathy was reversed with alpha and beta blockade prior to surgery.Case: A 56 year old female with 20 pack year smoking history, no regular medications and evidence of hypertension underwent CT AP for abdomin...

A 39 year old female patient presented with one week history of Shortness of breathing. Over the last four months she noted bilateral leg swelling, which failed to improve on diuretic. Examination revealed no other evidence of fluid overload or heart failure. An element of right heart strain rather than failure was raised on cardiologists review. Subsequently, an echo showed a friable mass extending form inferior vena cava to right atrium into proximal left ventricle. The natu...

Obesity is on the increase worldwide and mainly in women of reproductive age. In turn, it is associated with various reproductive complications. To assess the detrimental effect of obesity on reproductive health and the means of its management, this retrospective cohort study of 40 obese and infertile women has been conducted in the department of endocrinology and diabetology of Hedi Chaker hospital in Sfax-Tunisia from 2009 to 2014. These patients have a mean age of 34 years ...

Introduction: Central diabetes insipidus (CDI) is a rare but potentially dangerous dysregulation of the water balance secondary to an arginine vasopressin (AVP) deficiency. Diabetes insipidus may have different manifestations in children compared to adults. CDI is more common in children than nephrogenic diabetes insipidus.Methods: A retrospective study of eight patients collected in the pediatric department of Mahdia.Results: The ...

Background: Resistin is a hormone that potentially links obesity to T2DM. Several single nucleotide polymorphisms (SNPs) have been identified in the resistin gene (RETN). Polymorphism of RETN +299 (G>A) may contribute to increased resistin levels, which may be involved in the pathogenesis of T2DM.Aim of work: To study the association between resistin gene +299 polymorphism and insulin resistance in non-diabetic offspring of T2DM.<p class="abstext...

Introduction: Familial Hypocalciuric Hypercalcemia (FHH) is a benign autosomal dominant condition caused by an inactivating mutation on the gene coding for the Calcium Sensing Receptor (CASR). CASR plays a role in regulating parathyroid secretion and calcium metabolism. The majority of adults with FHH are asymptomatic. This is a case of three young brothers whose genetic tests shows two mutations in each of their CASR gene leading to hypercalcemia and varying symptoms.<p c...

Introduction: Ectopic thyroid tissue can be found anywhere along the normal path of thyroid descent, but is most commonly found at the base of the tongue, in which case it may be referred to as a lingual thyroid. Although the patients are usually asymptomatic, it can lead to symptoms such as dysphonia and dysphagia. We present a child patient with a lingual thyroid resulting in severe dysphagia that was cured surgically.Case reports: An 4-year-old male c...

Background and aims: The diabetic hand infection is less reported in the literature. Therefore, it is easily ignored and underestimated resulting in increased morbidity among the diabetic population. The aim is to determine the clinical and therapeutic characteristics in our hospitalized patients.Materials and methods: All hand infection patients admitted to the Department of Diabetes and Endocrinology at Oran University Hospital center during 10 years w...

Introduction: Recent observational evidence suggests strong links between low vitamin D levels and a range of cardiovascular risk factors, including hypertension, diabetes, obesity and hyperlipidemia. In addition increased rate of all-cause and cardiovascular mortality.Objectives: To determine 25-hydroxyvitamine D (25(OH) D) levels as well as its relationship with some cardiovascular risk factors among Egyptian Female patients with type 2 diabetes.<p...